DNMT1 and brain infarction: Moreover, the novelty is the scientific evidence which clearly demonstrates the nutrigenomic effect of GCJ via the modulation effect on an epigenetic mechanism by suppressing the expression of DNMT1 and HDAC3 in the cerebral cortex and gives rise to the reduction of inflammation and oxidative stress resulting in an increase of cortical neuron density and the reduction in brain infarction, brain edema, and neurological deficit as shown in Figure 7.