TP53 and neoplasm: El Bayoumy et al. previously reported several potential actions of selenium in cancer prevention and treatment, including delaying the oxidative damage of DNA, lipids, and proteins; inhibiting the growth of tumor cells; changing the synthesis of DNA, RNA, and proteins; regulating the cell cycle; inducing apoptosis; regulating the expression of p53, COX-2, modified transcription factor-activating protein P, and nuclear factor B [35, 36].