PHLPP1 and lung cancer: The expression of lncRNA-141 is decreased in gastric cancer cells, and it plays a tumor suppressor role by targeting signal transduction and transcriptional activator 4 [29]; LncRNA-141 is strongly expressed in nonsmall cell lung cancer (NSCLC) cells, where it promotes the proliferation, differentiation, and migration of NSCLC cells by inhibiting the expression of PHLPP1 and PHLPP2 and modulating the PI3K/Akt signaling pathway [30].