Moxibustion treatment regulated the expression of EGF and EGFR, and the metabolites (alanine, nicotinamide adenine dinucleotide phosphate, uracil DNA glycosylase, lactate, glycerol, and adenosine) induced by CAG in gastric tissues were restored to normal levels after moxibustion treatment, thus reducing the apoptosis of gastric mucosal cells and controlling acute and chronic gastric mucosal damage to treat spleen and stomach diseases. The gene discussed is EGFR; the disease is stomach disorder.