We found that missense mutation of FCGR3A was the primary type of gene alteration and I142Mfs∗21 alteration between the lg_2 domain, which was detected in one case of cervical squamous cell carcinoma, one case of lung squamous cell carcinoma, one case of uterine endometrioid carcinoma (Figure 9(b)), can induce a frameshift mutation of the FCGR3A gene, translation from I (isoleucine) to M (methionine) at the 142 sites of FCGR3A protein, and the subsequent FCGR3A protein truncation. The gene discussed is FCGR3A; the disease is squamous cell lung carcinoma.