The objectives were a) to confirm already diagnosed colorectal carcinoma by histopathological examination; b) to determine histological grades of CRC based on histopathological prognostic markers;m c) to determine staging of colorectal carcinoma by TNM classification based on American Joint Committee of Cancer (AJCC); d) to asses HER2 and Ki-67 expression in tumor tissues of colon and rectum by immunohistochemistry; e) to compare Ki-67 and HER2 expression with histopathological prognostic markers and TNM staging. This evidence concerns the gene ERBB2 and colorectal carcinoma.