Researchers using Cynomolgus monkeys have been able to create a primate model of C9orf72 related dipeptide repeats (DPRs) and show that poly (PR) DPRs are sufficient to induce C9-ALS/frontotemporal dementia (FTD)-like symptoms in primates (Xu L. et al., 2023). Here, C9orf72 is linked to amyotrophic lateral sclerosis.