A similar shift with lower IGFBP7 expression in ductal cells, and then an increase in intraparenchymal cells is seen in a cystic fibrosis-related diabetes (CFRD) animal model where IGFBP7 was suggested to mediate pathological intrapancreatic crosstalk.32 The gene discussed is IGFBP7; the disease is cystic fibrosis-related diabetes.