This syndrome is primarily inherited in an autosomal dominant manner, although rare cases of autosomal recessive inheritance have been reported. Some commonly known genetic mutations associated with TCS occur in the Treacle Ribosome Biogenesis Factor 1 (TCOF1) gene, although other genes such as POLR1B and POLR1C have been implicated. This evidence concerns the gene TCOF1 and Treacher-Collins syndrome.