Hereditary thrombophilia can be subdivided into two categories: 1) deficiency in coagulation inhibitors, like antithrombin III deficiency (AT III), protein C, and protein S deficiency and 2) elevation in coagulation factors, such as dysfibrinogenemia, increased levels of factors VIII, XI, IX, factor V Leiden, activated protein C resistance (APC), and prothrombin gene mutation. This evidence concerns the gene APC and hyperinsulinemic hypoglycemia, familial, 4.