There have been few rare case reports published linking corpus luteum hemorrhage to spontaneous hemoperitoneum in patients with bleeding disorders, including women with aplastic anemia, ITP, hemophilia or hemophilia carrier status, afibrinogenemia, von Willebrand disease, and factors X, VII, V, II, and XIII deficiency [1,8]. The gene discussed is F10; the disease is congenital afibrinogenemia.