There have been few rare case reports published linking corpus luteum hemorrhage to spontaneous hemoperitoneum in patients with bleeding disorders, including women with aplastic anemia, ITP, hemophilia or hemophilia carrier status, afibrinogenemia, von Willebrand disease, and factors X, VII, V, II, and XIII deficiency [1,8]. This evidence concerns the gene F10 and Familial afibrinogenemia.