In addition, the skeletal muscle releases IL-6 during exercise [11]. Moreover, research carried out on individuals has shown that IL-6 promotes the secretion of insulin by promoting the production of glucagon-like peptide-1 [12]. IL-6 is a proinflammatory cytokine that stimulates inflammation and contributes to the pathophysiology of T2DM. The gene discussed is INS; the disease is type 2 diabetes mellitus.