MAP2K7 and retinal disorder: FGFR signaling occurs upstream from MEK in the RAS/RAF/MEK/extracellular-signaling kinase (ERK) pathway and plays a role in retinal maintenance, protection, and repair [11,12]. Therefore, the inhibition of FGFRs may produce a similar clinical picture as MEK inhibitor-associated retinopathy (MEKAR), consisting of bilateral fluid collections between the RPE and IZ [13,14].