AD is used to study the formation of amyloid plaques and tauopathy; ALS is used to study the degeneration of motor neurons with introduced mutations in genes like SOD1 and TDP-43; and Huntington’s disease (HD) exhibits neurodegenerative phenotypes with mutant huntingtin (HTT) gene expression. As a result, using zebrafish as a model organism in ND research provides a strong foundation for identifying the underlying causes of these conditions and screening potential therapies. This evidence concerns the gene HTT and amyotrophic lateral sclerosis.