IL22 and Crohn disease: Th17 cells release IL-17A, which increases the production of proinflammatory cytokines such as IL-17, IL-22, and IL-26, resulting in enhanced neutrophil recruitment and cardiovascular complications [24]. Immune-mediated chronic inflammatory disorders such as psoriasis, ankylosing spondylitis, rheumatoid arthritis, and Crohn's disease are also related to IL-17 increase [25].