However, a recent report found that Lypd1, a peptide marker of VENs,77 is also selectively enriched in the striosome.78 If future studies demonstrate that VENs selectively project to the striosome, this association may serve as a substrate for limbic symptoms in compartment-selective neurodegenerative diseases.19,79. Here, LYPD1 is linked to neurodegenerative disease.