Transformer 2 alpha homolog (TRA2A), a serine/arginine-rich splicing factor, influences methylation of lncRNAs, in particular MALAT1, in esophageal carcinoma, by forming a complex with METTL14, RBMX, and KIAA1429, another m6A writers [136]. The gene discussed is TRA2A; the disease is carcinoma of esophagus.