Tudor domain proteins have also the ability to bind to methyl arginine and are molecular adaptors: the constituents of chromatin remodeling complexes, AT rich interactive 1A (ARID1A) and ARID4A interact with EZH2 and are mutated in hepatocellular carcinoma (HCC), liver, kidney, ovarian and colon cancers. The gene discussed is EZH2; the disease is hepatocellular carcinoma.