Table 2 identifies these studies in addition to those that examine other tumor marker-based assays. Importantly, the relationship between elevated PSA and GSU remains significant after stratifying for low-risk, favorable-intermediate, and unfavorable intermediate disease found at biopsy [40]. PSA is also an independent predictor of GSU regardless of the number of biopsy cores and technique used to target biopsy (including MRI-fusion biopsy) [41]. The gene discussed is KLK3; the disease is neoplasm.