Oxidized low-density lipoprotein receptor 1 (OLR1) promotes SULT2B1 expression by increasing c-MYC expression while knockdown the ORL1 downregulating c-MYC expression, which results in reducing SULT2B1 level as well as reduced glycolytic metabolism leading to decreased cancer cell growth and chemoresistance in colon cancer (Zhao et al., 2021; Huang et al., 2022). The gene discussed is MYC; the disease is cancer.