OLR1 and colonic neoplasm: Furthermore, another study has reported that SULT2B1 is highly expressed in chemoresistance colon cancer and radio-resistance tissues, which promotes cell proliferation and chemoresistance in colon cancer through its involvement in oncogenic signaling involving the OLR1/c-MYC/SULT2B1 axis (Zhao et al., 2021; Huang et al., 2022).