DOCK2 and colonic neoplasm: Furthermore, cholesterol sulfate inhibits dedicator of cytokinesis protein 2 (DOCK2), a Rac activator crucial for lymphocyte activation and migration, decreasing CD8+ T cell infiltration into colon cancer tissues (Sakurai et al., 2018; Tatsuguchi et al., 2022b; Morino et al., 2023; Wang et al., 2023).