Paradoxically, butyrate-induced apoptosis in human CRC cells is correlated with an upregulation of Wnt signaling, which was previously reported as tumor-promoting signaling (Bordonaro et al., 1999; Zeng et al., 2014; Imkeller et al., 2022; Bordonaro et al., 2008), suggesting Wnt-dependent tumor-suppressive actions of SCFA-induced activation of GPR43. This evidence concerns the gene FFAR2 and colorectal carcinoma.