Indeed, we noted that majority of the gene sets now implicated pathways relevant to the pancreatic islets and metabolic tissues, such as “abnormal glucose homeostasis”, “peptide hormone secretion”, “Maturity Onset Diabetes of the Young”, and multiple pathways involved in the regulation of glycogen, incretins, and carbohydrate metabolism, that were also seen in the FG only analysis (Figure 1D, Supplementary Table S5D, Supplementary Figure S2D11). This evidence concerns the gene GCG and diabetes mellitus.