HIBCH and type 2 diabetes mellitus: Initially, increased expression of SPATA20 and STYXL1 in the three tissues was causally linked to an elevated risk of T2DM, with an opposite causal effect observed for HIBCH. Only HIBCH was supported by colocalization evidence in the liver (PP.H4 = 0.85), pancreas (PP.H4 = 0.76), and VAT (PP.H4 = 0.76).