For example, within the GCDH, methylation at the cg17414007 was associated with an increased risk of T2DM (OR = 1.138, 95% CI = 1.116-1.161), while methylation at the cg21050076 was associated with a decreased risk of T2DM (OR = 0.891, 95% CI = 0.876-0.905). This evidence concerns the gene GCDH and type 2 diabetes mellitus.