Specifically, 13 CpG sites exhibited strong colocalization with T2DM, including ACSL1 (cg03977443), COQ4 (cg14458731), COX19 (cg22301154), DHRS4 (cg20021513), DNAJC11 (cg01053213, cg24361350), GCDH (cg17414007, cg21050076), ISCA2 (cg16374328), MTFMT (cg25698089), SLC25A16 (cg01284033), TRUB2 (cg14458731), and TUFM (cg00348858). The gene discussed is COQ4; the disease is type 2 diabetes mellitus.