Finally, methylation at LARS2 (cg04459086, cg13510812 and cg17683948) and SUCLG2 (cg00837649, cg07438401, cg11197418, cg13668339 and cg19433066) was causally associated with an increased risk of T2DM coma and ketoacidosis, respectively, with consistent directions of causal effects across CpG sites within the same gene. The gene discussed is LARS2; the disease is type 2 diabetes mellitus.