Specifically, 13 CpG sites exhibited strong colocalization with T2DM, including ACSL1 (cg03977443), COQ4 (cg14458731), COX19 (cg22301154), DHRS4 (cg20021513), DNAJC11 (cg01053213, cg24361350), GCDH (cg17414007, cg21050076), ISCA2 (cg16374328), MTFMT (cg25698089), SLC25A16 (cg01284033), TRUB2 (cg14458731), and TUFM (cg00348858). This evidence concerns the gene ISCA2 and type 2 diabetes mellitus.