Since then, the correlation between different GHR genotypes and systemic comorbidities in acromegalic patients has been examined by numerous studies, that were mainly focused on hypertension, obesity, diabetes mellitus type 2, colonic polyps, heart disease, obstructive sleep apnea syndrome, bone fragility, and heart disease (23–28), without reaching univocal findings. The gene discussed is GHR; the disease is heart disorder.