The positive effects in lowering IGF-I secretion of d3-GHR isoform in Peg-V treated patients and of fl-GHR isoform in Pasi-LAR treated patients may therefore induce a better biochemical control of acromegaly and in parallel may reduce the risk of the occurrence of VFs, which recognize among the main risk factors the persistence of high IGF-I levels. This evidence concerns the gene IGF1 and acromegaly.