Cluster 2 (C2, i.e., kinase signaling cluster) would mainly include RET, NF1, TMEM127, MAX, H-RAS, KIF1Bβ, MERTK, MET, MYCN and ATRX, which belongs to the SWI/SNF family of chromatin remodeling proteins, as their upregulation will activate the PI3K/AKT and RAS/MAPK signaling pathways resulting in tumor formation. This evidence concerns the gene ATRX and neoplasm.