Considering that these tumors (four parathyroid adenoma and one each of neuroblastoma, ganglioneuroblastoma/ganglionoma, and C-cell hyperplasia), PPGL, and PitNETs all originate from embryonic neural crest cells on histological examination, it is reasonable to assume that MAX mutations may trigger such tumors. This evidence concerns the gene MAX and parathyroid gland adenoma.