Although the MAX mutation is classified as type C2, including RET, NF1, TMEM127,H-RAS and ATRX, which belongs to the SWI/SNF family of chromatin remodeling proteins, as their upregulation will activate the PI3K/AKT and RAS/MAPK signaling pathways resulting in tumor formation (41). This evidence concerns the gene TMEM127 and neoplasm.