Overexpression or depletion of DCLK2203 can correspondingly promote or inhibit TBK1 activity, as indicated by phosphorylation of Ser172 on TBK1 and Ser366 on p62 (also known as SQSTM1), a downstream target of TBK1 in ccRCC (Hu et al., 2020) (Fig. 1E). The gene discussed is TBK1; the disease is nonpapillary renal cell carcinoma.