Among them, 5-HT1A (also known as HTR1A) and 5-HT7 (also known as HTR7) receptors have attracted considerable attention for their roles in mood disorders, such as depression and anxiety (Albert and Vahid-Ansari, 2019; Bijata et al., 2022a; Hedlund et al., 2005; Hirvonen et al., 2008; Lemonde et al., 2003). The gene discussed is HTR7; the disease is major depressive disorder.