INS and obesity due to melanocortin 4 receptor deficiency: It plays a vital role in multiple biological functions, including the regulation of host defense,[12] cell migration,[13] activation of autophagy,[14] and inflammatory signals.[11] Our previous study found that myeloid derived GCA instigated obesity‐induced insulin resistance and metabolic inflammation.[15] As obesity significantly increases the risk of developing MASLD and ≈80% of patients with MASLD are obese,[16] this prompted us to conjecture the unique biological significance of GCA in MASLD.