However, it was also accompanied by weight loss, lower insulin levels and lack of insulin resistance.[27] MASH developed via HFFC‐induced and HFD‐induced diet is highly similar to that in humans, but it requires a long feeding period and liver fibrosis is often not particularly obvious.[28] As expected, the GCA gain/loss‐of‐function enhanced or ameliorated liver steatosis and inflammation in multiple classical MASH models. Here, INS is linked to metabolic dysfunction-associated steatohepatitis.