RYR2 and heart failure: To better understand the mechanistic underpinnings that result in leaky RyR2 channels that play a role in heart failure and arrhythmogenic disorders, we analyzed the structures of the calstabin-depleted phosphomimetic RyR2-S2808D channel and two CPVT-linked mutant channel structures, RyR2-R420Q and RyR2-R420W.