Beyond other genes in our study, sexually dimorphic response patterns were observed for PGC-1α, a master regulator of mitochondrial biogenesis and transcriptional factor relevant for podocyte homeostasis [119] and a known role in kidney diseases [65], and Ctsl, encoding a cysteine protease which promotes Cd2ap and synaptopodin proteolysis [57, 120]. The gene discussed is CTSB; the disease is kidney disorder.