XBP1 and hereditary clear cell renal cell carcinoma: Other transcription factor candidates for sexual dimorphic gene expression patterns in our study identified by IPA were e.g. Xbp1, and KDM5a. Kdm5a mediates kidney failure in lipopolysaccharide-induced sepsis of mice [100], induces stem-like cancer cells and promotes renal cell carcinoma [62, 101].