Interestingly, the expression of genes and proteins involved in fatty acid metabolism, such as Elovl2 and Fads2, are regulated through their DNA methylation status [44, 45]; however, we did not observe definitive increases the methyl donor-associated lipid profiles in LPD compared to MD-LPD or WD compared to MD-WD. This evidence concerns the gene ELOVL2 and Menkes disease.