Response to LPD and MD-LPD had no common biological process influences, whereas WD and MD-WD both showed common changes to the modulation of age-related behavioural decline (GO:0090647) and the response to cadmium ion (GO:0046686), both due to changes in beta-2-microglobulin and major prion protein. The gene discussed is B2M; the disease is Menkes disease.