Additionally, the study identifies nordihydroguaiaretic acid (NDGA) as an effective therapeutic agent that directly binds to RARγ and inhibits the TRAF6-IL-6-STAT3 signaling pathway, offering a new therapeutic strategy targeting pro-tumoral macrophages in CRC.406 In another study, researchers conducted a global mapping of HPTMs in CRC cells treated with largazole-7. Here, TRAF6 is linked to colorectal carcinoma.