PGAM1 and liver cancer: The Numb/Parkin pathway acts as a critical metabolic regulator and emerges as a potential therapeutic target in oncology.187 Aspirin notably decreases overall succ levels in liver cancer cells, including the succ of phosphoglycerate mutase 1 (PGAM1), thereby curtailing the glycolytic process.188 For instance, research conducted by Pandkar and their team indicated that decreasing glycolytic activity, especially by inhibiting histone la, significantly reduces the expression of the c-Myc gene, which in turn hinders the advancement of breast cancer.189