UBE2I and melanoma: Significantly, increased levels of Ubc9 have been detected in a range of cancers such as lung,236 prostate,237 ovarian,238 bladder cancer239 and melanoma.240 One research demonstrates that inhibiting UBC9 curtails tumor development in mouse xenograft models, while the depletion of Ubc9 fosters STAT4-mediated macrophage activation.