Experimental findings suggest that by obstructing the nuclear entry of the α-ketoglutarate dehydrogenase complex or suppressing the expression of KAT2A (Tyr645Ala), one can diminish gene expression, which consequently reduces the proliferation of tumor cells and overall tumor expansion.126 Concurrently, studies have shown that genomic instability is a hallmark of cancer.226 This association between histone succ and DNA damage has been underscored by several studies.227 To sum up, research has demonstrated that histone succ, regulated by KAT2A or HAT1, is pivotal in governing gene expression. Here, HAT1 is linked to cancer.