Nonetheless, the new “SHBG-LpA” cluster confirms the previously suggested inverse causal association between SHBG and T2D risk.4 Despite the absence of an association of this cluster with indices of insulin resistance, the cluster-specific enrichment epigenomic annotations in fetal hepatoblasts may be related to the confirmed inverse association of SHBG with intrahepatic lipids. This evidence concerns the gene SHBG and type 2 diabetes mellitus.