Using a soft clustering method for the analysis of multiple ancestry-based data, Smith and colleagues identified 12 genetic clusters, of which three can be related to insulin deficiency (“Beta Cell 1”, “Beta Cell 2” and “Proinsulin)”, and seven to insulin resistance (“Obesity”, “Lipodystrophy 1”, “Lipodystrophy 2”, “Hyper Insulin”, “Cholesterol”, “Liver-Lipid” and “ALP Negative”), whereas two were related to currently unclear mechanisms (“Bilirubin” and “SHBG-LpA”) (Fig. 1). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.