At consensus meetings under the auspices of the National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of Biomedical Imaging and Bioengineering (NIBIB), a required feature of the proposed 2016 article definition [phosphorylated tau (p-tau) aggregates within astrocytes] [52] was dropped in the updated definition of 2021, while an additional nuance—the depth of p-tau aggregates relative to the pial surface—was added [51]. This evidence concerns the gene MAPT and stroke disorder.