However, we did not observe any significant differences in the levels of key components of the AKT/mTOR pathway, nor did we detect an enrichment in the dysregulation of polymerase or ribosomal protein genes (Supplementary Material, Fig. S4 and Supplementary Material, Table S1), suggesting other mechanisms may be driving gene dysregulation in MDS iNeurons. This evidence concerns the gene AKT1 and myelodysplastic syndrome.