TNFAIP8 and Insulin resistance: In a serum proteomics study of 35,559 individuals62, the effect allele (chr5:118729286:C:T) of the lead putatively causal variant rs1045241, which was associated with decreased TG/HDL also was significantly associated with decreased plasma levels of TNFAIP8 (effect size = −0.05, p = 8.7 × 10−10), suggesting TNFAIP8 promotes insulin resistance.