INS and metabolic disease: We computed the genetic correlations37 between our TG/HDL GWAS and previous association studies of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)12, Homeostatic Model Assessment for Beta Cell Function (HOMA-B)38, fasting insulin (FI)14, fasting glucose (FG)14, waist-hip ratio adjusted for BMI (WHR)13, 2 hour glucose (2 h glucose)11, glycated hemoglobin (HbA1c)11, Modified Stumvoll Insulin Sensitivity Index (ISI)39 as well as metabolic disease sequelae including NAFLD40, T2D41, CVD42 (Fig. 1b, Supplementary Data 3).