The re-identification of loci known to encode insulin signaling components (e.g., INSR, IRS1), as well as those identified by previous surrogate biomarker studies, confirms the fidelity of TG/HDL as a surrogate marker of insulin resistance, providing confidence that the 29 novel loci in the top-quartile of boost scores identified could be true mediators of insulin resistance. This evidence concerns the gene IRS1 and Insulin resistance.