At the COBLL1 locus, our genetically predicted gene expression analysis indicated that increased gene expression of COBLL1 primarily in adipocytes (subcutaneous: t-statistic = −8.8, p = 2 × 10−16; visceral: t-statistic = −9.7, p = 4.8 × 10−20; liver: t-statistic = 3.0, p = 0.03; muscle: t-statistic = −3.5, p = 0.007) is associated with decreased TG/HDL which aligns with recent work showing that LOF in COBLL1 results in insulin resistance through adipose-specific mechanisms44. The gene discussed is COBLL1; the disease is Insulin resistance.