To confirm the protective role of TRPS1 in BC cells against chemo-mediated killing, we performed ADR sensitivity assays on a panel of BC cell lines, comparing cells with endogenously high TRPS1 expression (TRPS1High) to those with low/undetectable TRPS1 expression (TRPS1Low) (Fig. 1D). The gene discussed is TRPS1; the disease is breast cancer.