Dysregulation in multiple subsets of Tregs, including both conventional thymus-derived Tregs and less conventional peripherally-induced Tregs, has been reported in the peripheral blood of patients with cirrhosis and AD.16, 17, 18, 19, 20, 21 Our previous study identified an expanded CD4+HLA-G+IL-35+ suppressive T cell population in AD which was transcriptomically characterised by the high expression of CD52.21 Here, CD4 is linked to Alzheimer disease.