SIRT1 and sarcopenia: Additionally, although we identified plasma EEF1E1 as a potential marker of sarcopenia and observed its ability to influence myoblast senescence, SIRT1 and autophagy when introduced into cell media, the present study did not elucidate how EEF1E1 interacts with SIRT1 and autophagy, nor did it clarify the regulatory relationship between SIRT1 and autophagy.