In Lewis Lung carcinoma (LLC) lung cancer cells, evidence suggests that PLB interactions with Thioredoxin Reductase (TrxR) prevent its downstream interactions with intracellular substrates and directly inhibit Glutathione Reductase (GR), thereby mediating the increase of intracellular ROS levels and ultimately leading to apoptosis [12]. Here, GSR is linked to Carcinoma, Lewis Lung.