As regards the combination BER with palmatine, we found that for some newly emerged targets, such as those related to cell cycle regulation and antiproliferative activity, corroborative data emerged from an In Vitro study on cancer cells [58,59,60,61]; moreover, BDNF and cholinesterase (BCHE) emerged as neuro-targets, and some important antioxidant targets such as catalase (CAT) and superoxide dismutase (SOD) were shared by BER and palmatine, as well as the xenobiotic toxicity modulator aryl-hydrocarbon receptor (ARH) [62]. The gene discussed is BDNF; the disease is cancer.