↓ The serum level of insulin, fasting glucose;↑ Insulin resistance;↓ The accumulation of lipid droplets in the liver and the liver weight;↓ The contents of TC and TG, the levels of ALT and AST, and LDL-C;↑ The content of HDL-C;↑ The activities of SOD and GSH;↓ The content of MDA in the liver;Accelerated the translocation of Nrf-2 from the cytoplasm to nuclei in the liver;↓ The mRNA levels of FAS and ACC1 in the liver;↓ The expression of Bcl-2, Bax, and HO-1 in the liver. The gene discussed is INS; the disease is Insulin resistance.