IL1A and Insulin resistance: In individuals with NAFLD, lipotoxicity, insulin resistance, and endotoxins trigger the activation of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and resistin [3].