The phenolic compounds present in plant extracts can inhibit the migration of melanoma tumor cells by modulating signaling pathways (MAPK/ERK, PI3K/Akt, NF-κB, JAK/STAT, and TGF-β) and enzymes responsible for degrading the extracellular matrix, including matrix metalloproteinases and integrins [65]. The gene discussed is AKT1; the disease is neoplasm.