Therefore, given the complex pathophysiology of diabetic retinopathy, which involves multiple mechanisms including oxidative stress and VEGF-mediated pathways [4], the multifaceted action of MaGPE—relevant in the inhibition of a-glucosidase activity—as a potent antioxidant and inhibitor of carbohydrate-metabolizing enzymes, could address several aspects of disease progression [35]. The gene discussed is VEGFA; the disease is diabetic retinopathy.