[11C]SSR180575, the 2-(7-chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide (12, Figure 5, Table 1) was developed based on high affinity (Ki = 0.83 nM) and selectivity for TSPO of SSR180575, as well as the ability to support neuronal survival and regeneration in animal models of axotomy and neuropathy by facilitating the local synthesis of neurosteroids [44]; 12 exhibited substantial TSPO-specific binding, as demonstrated in a rodent model of acute neuroinflammation. This evidence concerns the gene TSPO and neuropathy.