AKT1 and oral cavity squamous cell carcinoma: They found that cucurbitacin B can regulate the expression of the PI3K-AKT pathway and reduce the expression levels of p-PI3K, p-AKT, and p-mTOR, thus inhibiting the migration of human tongue squamous cancer cells, blocking the cell cycle in the G2 phase, and inducing cell apoptosis, which inhibits the growth of oral squamous cell carcinoma.