In another study on the same PD rat models, pretreated with ellagic acid (50 mg/kg/day for one week), it was demonstrated that the supplementation reduced oxidative stress and apoptosis phenomena and improved MAO-B, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and heme oxygenase 1 (HO-1) [86]. This evidence concerns the gene HMOX1 and Parkinson disease.