ERBB2 and breast cancer: On the contrary, Zhang et al. (2017) showed that, in both MDA-MB-231 (invasive TNBC, lacks estrogen receptor (ER) and progesterone receptor (PR) expression, as well as human epidermal growth factor receptor 2 (HER2) amplification) and MCF7 (luminal A molecular BC subtype, ER and PR positive) BC cell lines, deglycosylation of the epithelial cell adhesion molecule (EpCAM) promotes similar effects [35].