As in other cancer types, in BC, numerous proteins encoded by both oncogenes (i.e., EGFR, PD-L1) or tumor-suppressor genes, such as scribble (SCRIB), are palmitoylated, leading to modification in their cell localization, PPI, and signal transduction, sustaining cell proliferation, metastasis, and tumor immunity [175]. The gene discussed is CD274; the disease is breast cancer.