Ren et al. (2013) showed that AR and its phosphorylation at Ser213/650 are differentially expressed in BC tumorigenesis and cancer progression; thus, phosphorylation at Ser213/650 was detected as increased in primary ER-negative BC, ductal carcinomas, and metastases compared to benign tissue and could have predictive value in BC prognosis [44]. The gene discussed is ESR1; the disease is breast cancer.