Thus, acetylated chromatin becomes loose and can be related to activated transcription, while deacetylated chromatin is supercoiled and could be associated with the inhibition of the expression of tumor-suppressor genes in BC [212] like breast cancer susceptibility gene 1 (BRCA1), a tumor-suppressor gene involved in DNA repair, cell cycle, and genome stability [215]. The gene discussed is BRCA1; the disease is breast cancer.