SNAIL phosphorylation by activated ERK2 at Ser82/104 [147] and large tumor suppressor kinase 2 (LATS2) at Thr203 [148] leads to SNAIL nuclear localization, increasing its stability and activity, and allows it to escape from TRCP-mediated polyubiquitination and degradation, facilitating BC metastasis [138]. Here, SNAI1 is linked to breast cancer.