Zhang et al. (2017) showed that, in MDA-MB-231 and MCF7 BC cell lines, deglycosylation of EpCAM promoted apoptosis, downregulating the expression of anti-apoptotic protein Bcl-2 and overexpressing the expression of pro-apoptotic proteins Bax and caspase-3 through the ERK1/2 and JUK/MAPK signaling pathways [35]. Here, MAPK3 is linked to breast cancer.