Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that these active ingredients target key pathways such as the glucocorticoid receptor (NR3C1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), tumor antigen p53 (TP53), transcription factor AP-1 (JUN), mitogen-activated protein kinase 1 (MAPK1), Myc proto-oncogene protein (Myc), cyclin-dependent kinase 1 (CDK1), and ATP-binding cassette transporter ABCG2 (ABCG2) in the treatment of colorectal cancer. Here, PIK3CA is linked to colorectal cancer.