AKT1 and cancer: Zhang et al.’s network pharmacology study suggested that flavonoids such as quercetin, luteolin, and wogonin in SBD downregulate mRNA expression of ovarian-cancer-related genes including AKT1, VEGFA, JUN, TNF, and Caspase-3, inhibiting the PI3K/Akt signaling pathway, thereby inhibiting cancer cell proliferation and inducing apoptosis [111].