BCHE and Alzheimer disease: While natural antioxidants offer a new approach to treating AD, traditional therapies include cholinesterase inhibitors, such as donepezil, galantamine, and rivastigmine [65], N-methyl-D-aspartate (NMDA) receptor antagonists (memantine), or monoclonal antibodies (lecanemab and donanemab) recently approved after clinical trials [117].