Bcl-2 is a pivotal regulator of apoptosis, often overexpressed in various cancers, including chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), breast cancer, and lung cancer, allowing cancer cells to evade apoptosis, leading to chemoresistance and poor prognosis [63,64,65]. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.