Instead, some authors [34,38] discussed three explanations for the symmetric thinning of RNFL under anti-VEGF therapy: age-related RNFL loss [38,39,40,41,42], nonexudative AMD in the fellow eye [34], and/or contralateral effect of anti-VEGF due to systemic circulation. The gene discussed is VEGFA; the disease is age-related macular degeneration.